NEnglJMed;:-January14,DOI:10./NEJMoaBACKGROUND

Tuberculousmeningitisisoftenlethal.Earlyantituberculosistreatmentandadjunctivetreatmentwithglucocorticoidsimprovesurvival,butnearlyonethirdofpatientswiththeconditionstilldie.WehypothesizedthatintensifiedantituberculosistreatmentwouldenhancethekillingofintracerebralMycobacteriumtuberculosisorganismsanddecreasetherateofdeathamongpatients.

METHODS

Weperformedarandomized,double-blind,placebo-controlledtrialinvolvinghumanimmunodeficiencyvirus(HIV)–infectedadultsandHIV-uninfectedadultswithaclinicaldiagnosisoftuberculousmeningitiswhowereadmittedtooneoftwoVietnamesehospitals.We







































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